GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs61826828 | 1 | rs61826828 | chr1:174015261 | SERPINC1 | chr1:173872943-173886516:- | 0.58 | 8.64 | 8.47E-17 | Schizophrenia |
| THCA | cis | rs10789491 | 1 | rs618505 | chr1:47144532 | CYP4Z1 | chr1:47533160-47583992:+ | 0.26 | 3.89 | 0.000112 | Response to hepatitis C treatment |
| THCA | cis | rs10789491 | 1 | rs618505 | chr1:47144532 | DMBX1 | chr1:46972668-46979884:+ | 0.23 | 4.04 | 6.19E-5 | Response to hepatitis C treatment |
| THCA | cis | rs4925540 | 1 | rs61852630 | chr1:247210193 | OR2T8 | chr1:248084320-248085256:+ | -0.18 | -3.43 | 0.000665 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs4925540 | 1 | rs61852630 | chr1:247210193 | OR2W3 | chr1:248031265-248060142:+ | -0.18 | -3.62 | 0.000328 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs4925540 | 1 | rs61852630 | chr1:247210193 | TRIM58 | chr1:248020501-248043436:+ | -0.15 | -3.38 | 0.000771 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs4925540 | 1 | rs61852637 | chr1:247219636 | OR2T8 | chr1:248084320-248085256:+ | -0.19 | -3.56 | 0.000405 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs4925540 | 1 | rs61852637 | chr1:247219636 | OR2W3 | chr1:248031265-248060142:+ | -0.18 | -3.61 | 0.000336 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs4925540 | 1 | rs61852637 | chr1:247219636 | TRIM58 | chr1:248020501-248043436:+ | -0.15 | -3.34 | 0.000894 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs11203032 | 1 | rs61853072 | chr10:90961500 | CH25H | chr10:90965696-90967071:- | 0.48 | 8.11 | 4.38E-15 | Heart failure |
| THCA | cis | rs6479891 | 1 | rs61853336 | chr10:64899875 | LOC84989 | chr10:65224989-65226320:+ | 0.27 | 4.37 | 1.49E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs61853336 | chr10:64899875 | NRBF2 | chr10:64893007-64914785:+ | 0.27 | 4.62 | 5.02E-6 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs61853589 | chr10:65187111 | LOC84989 | chr10:65224989-65226320:+ | 0.26 | 4.13 | 4.27E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs61853589 | chr10:65187111 | NRBF2 | chr10:64893007-64914785:+ | 0.27 | 4.45 | 1.09E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs61853635 | chr10:65276510 | LOC84989 | chr10:65224989-65226320:+ | 0.27 | 4.31 | 1.98E-5 | Arthritis (juvenile idiopathic) |